Cica Micro-Shot Infusion Liquid Micro-Needling Serum (Patented Korean Spicule Technology)

PDRN 2%

PDRN (Polydeoxyribonucleotide) is a bioactive DNA fragment naturally derived from salmon. These low–molecular weight nucleotides are known for their ability to support skin cell regeneration and tissue repair, making them a powerful ingredient in advanced skin-rejuvenation formulations.

PDRN closely resembles human DNA in structure, which allows for high skin compatibility and optimal biological activity. It works by activating A2A adenosine receptors, helping to:

• Stimulate collagen synthesis
• Reduce inflammation
• Strengthen the skin barrier

PDRN has been widely used in medical wound and burn care in Korea and has recently gained global recognition through advanced K-beauty skin-repair treatments.

Intelligent Regenerative Skincare

Exosomes 2%

Exosomes are extracellular vesicles involved in intercellular signaling. They carry bioactive molecules such as proteins, lipids, and nucleic acids that influence cellular repair and regeneration pathways.
For cosmetic use, exosomes are typically derived from mesenchymal stem cell sources and formulated into topical products to support skin rejuvenation and barrier function.

Exosome-based serums are advanced cosmetic formulations designed to support skin regeneration and anti-aging through enhanced cellular communication.

Melazero™ 1% (Japan)

Patented third-generation depigmenting active

Derived from Arisaema amurense, Melazero™ is a patented third-generation brightening active with a novel mechanism of action.

Melazero™ harnesses autophagy—a Nobel Prize–winning cellular renewal pathway—to support the breakdown and recycling of accumulated melanin.

Hyperpigmentation is a widespread skin concern resulting from increased melanin synthesis. Melanin, derived from the amino acid tyrosine, is a group of pigments that determine skin color, primarily in the form of eumelanin and pheomelanin.

Most conventional brightening actives focus solely on reducing new melanin production, offering limited benefit against pigment already deposited in the skin.

This is where Melazero™ stands apart. In addition to controlling melanin synthesis, Melazero™ helps reduce existing pigment accumulation beneath the skin while limiting further melanocyte activity—delivering a more comprehensive and effective brightening approach. Let us explore the advanced mechanism behind Melazero™ and its superior skin-brightening action.

Niacinamide 5%

Niacinamide 5% is a high-performance skincare active that helps refine skin texture, minimize blemishes, and enhance overall skin quality.

Also known as vitamin B3, niacinamide is a water-soluble vitamin celebrated for its wide-ranging skin benefits. Commonly used in advanced serums and moisturizers, a 5% strength provides effective results without compromising skin comfort.

Alpha Arbutin 2%

Alpha Arbutin, a bioengineered derivative of bearberry extract, is a well-recognized brightening ingredient known for its ability to regulate melanin production. By helping fade dark spots and discoloration, it supports clearer, more radiant skin. A 2% formulation offers optimal performance, providing noticeable skin tone correction and brightening benefits.

Sodium Hyaluronate 8M – 1.5%

Sodium Hyaluronate 8M at 1.5% provides deep, long-lasting hydration by attracting and retaining moisture on the skin surface. Its high molecular weight structure enhances skin suppleness, smoothness, and plumpness while reinforcing the skin barrier and aiding recovery after micro-spicule action.

 
Ethyl Ascorbic Acid 3%

 Ethyl Ascorbic Acid 3% is a stable, water-soluble form of vitamin C that penetrates the skin effectively to provide antioxidant protection and visible brightening. Commonly used in modern skincare formulations, it offers improved stability compared to traditional vitamin C. Its balanced pH range makes it suitable for cosmetic use, supporting a brighter, healthier-looking complexion.

 
Micro-Spicules (0.2%)

“Spicule-based skincare is a microneedling-inspired, needle-free delivery technology designed to enhance topical absorption.”

Melazero™ demonstrates superior brightening efficacy compared to conventional depigmenting agents.
Clinical evaluations indicate that Melazero™ delivers up to 2× greater pigment reduction than alpha-arbutin. At a concentration of 1%, Melazero™ exhibits stronger melanin inhibition than 2% kojic acid, without inducing the cellular toxicity associated with higher kojic acid concentrations.

Unlike traditional brightening actives that require up to four weeks to show visible results, Melazero™ provides noticeable improvement in skin tone within two weeks, enabling faster and more effective pigmentation correction.

Spicule

Clinical studies on crow’s-feet reveal that when spicules are combined with active ingredients, skin density improves significantly compared to actives alone. Additional findings show that spicules increase skin permeability, enabling deeper and more efficient delivery of topical actives. By creating ultra-fine micro-channels in the epidermis, spicules help transcend the skin’s natural barrier—unlocking the full potential of peptides, retinoids, and antioxidants.

•  Targets Hyperpigmentation at the Source
•  Controls Melanin Synthesis
•  Enhances Skin Brightness & Tone Uniformity
•  Boosts Hydration & Skin Suppleness
•  Supports Anti-Aging & Photoprotection

1. Micro-Spicules (0.2%)
Ultra-fine hydrolysed spicules create micro-pathways in the epidermis.

• Enhances penetration up to 5X compared to conventional serums
• Stimulates mild skin renewal response
• Ensures actives reach deeper layers effectively

2. Deep Cellular Repair & Regeneration
PDRN and Exosome work at the cellular communication level, supporting skin repair, collagen synthesis, and tissue renewal.

3. Melanin Regulation & Brightening
Multi-pathway inhibition of melanin formation ensures visible brightening without irritation.

4. Hydration & Barrier Restoration
Multi-molecular humectants maintain deep hydration and reduce post-procedure sensitivity.

Within 7 Days

• Improved hydration
• Visible glow
• Smoother skin texture

Within 14 Days

• Reduction in dullness
• Early improvement in uneven tone
• Skin looks healthier and plumper

Within 21–28 Days

• Noticeable reduction in pigmentation
• Enhanced brightness and clarity
• Improved elasticity and skin firmness

After 4–6 Weeks

• Even skin tone
• Long-term pigmentation control
• Strengthened skin barrier and radiance

(Results may vary based on skin type and adherence to usage protocol)

Skin Sensitivity Check

At Healthy Nutrea, skincare is approached with care and responsibility. Our goal is not just results, but safety and confidence with every use. To help ensure suitability, we recommend performing a skin compatibility test before first use.

How to Perform the Test

1. Clean a small area on the upper forearm and apply a small amount of the product
2. Allow it to remain undisturbed for 15–20 minutes (up to a maximum of 30 minutes)
3. If itching, redness, burning, blistering, or irritation occurs, rinse the area thoroughly and discontinue use

Important Note

This test is intended only to identify early signs of local skin irritation. It does not guarantee similar results when applied to other areas of the body, including the face, or after prolonged or repeated use.
This test does not evaluate underlying skin conditions and should not be used to diagnose hypersensitivity or allergic contact dermatitis.

Product Information & Safety Notes

Natural variations may occur. Patch testing is recommended. Discontinue use if irritation develops. External use only. Store appropriately. Results may vary.

WHEN TO USE

✘ Do not use daily

✘ Avoid combining with other exfoliating or retinol products on the same night

FREQUENCY SCHEDULE

Month 1: Apply 2 times a week

Month 2: Apply 3 times a week

Month 3: Apply 4 times a week

After 1 Month:

Maintain a 2-day gap if skin feels sensitive.

Once skin adapts:

Preferred use is twice weekly.

Cautious

Exposure to heat, LED light therapy, or stimulation from skincare tools (such as LED masks, RF, or ultrasonic devices) may increase skin sensitivity and could lead to irritation. Concurrent use is not advised.

How to use a microneedle serum on your face?

Microneedle facial care is a step-by-step process that begins with thoroughly cleansing the skin to remove dirt, excess oil, and daily environmental impurities. Once the skin is clean and dry, apply a dermatologically developed microneedle treatment serum evenly across the face.

While applying, avoid direct contact with the eye area and use gentle, even pressure to allow the micro-spicules to activate effectively on the skin’s surface. A nozzle-based dispensing system helps deliver a precise, pea-sized amount, ensuring controlled and hygienic application.

For best results, follow with a calming moisturizer to help support skin comfort and hydration.


Is PDRN & Exosome suitable for microneedle serum treatments?

Yes. PDRN and Exosome technology is widely valued in advanced skincare for its ability to support skin repair, renewal, and overall skin resilience. When paired with a microneedle delivery system, these actives are able to reach the skin more effectively, helping improve texture, comfort, and barrier strength.

This combination makes PDRN & Exosome microneedle serums a suitable option for those seeking a gentle, science-driven at-home microneedling-inspired experience.


How often should a microneedle serum be used?

A dermatology-inspired microneedle serum can be used three to four times a week, depending on skin tolerance. Consistent use, along with proper moisturization and sun protection during the day, helps support gradual and visible skin improvement over time.


Is the PDRN & Exosome Microneedle Serum effective?

Yes. Designed with dermatological insight, the PDRN & Exosome Microneedle Serum is formulated to enhance ingredient delivery through ultra-fine micro-spicules. This advanced delivery system supports improved absorption and helps promote a healthier-looking skin renewal process. Supporting ingredients such as Niacinamide, Alpha Arbutin, Ethyl Ascorbic Acid, Sodium Hyaluronate  help maintain hydration and comfort, making the formula suitable for regular use.


What is the PDRN & Exosome Microneedle Serum used for?

The PDRN & Exosome Microneedle Serum can be used for individuals looking to support:

• Skin repair and recovery
• Improved texture and smoothness
• Strengthened skin barrier
• Overall skin quality and resilience

Dermatologically designed for both men and women, the formula is suitable for regular use and fits seamlessly into a modern skincare routine focused on long-term skin health.


What is a microneedle serum shot?

A microneedle serum shot is an advanced skincare format infused with ultra-fine, needle-like spicules that support enhanced delivery of active ingredients. The PDRN & Exosome Microneedle Serum Shot helps create temporary micro-pathways on the skin’s surface, allowing actives to absorb more effectively and work where they matter most.


What does this microneedle serum do?

The PDRN & Exosome Microneedle Serum Shot is a dermatology-inspired, at-home microneedling alternative designed to support skin recovery and renewal. Powered by PDRN and Exosome technology, the serum helps improve skin texture, promote a smoother appearance, and support overall skin resilience with consistent use.


Can I use a PDRN & Exosome microneedle serum if I have sensitive skin?

Yes. Dermatologically designed, the PDRN & Exosome Microneedle Serum Shot is suitable for all skin types, including sensitive skin. After application, a mild needle-like or tingling sensation may be experienced for a short time—this is a normal response associated with the microneedle-inspired delivery system. Always follow with a soothing moisturizer to support skin comfort.


Are there any precautions to take when using a PDRN & Exosome Microneedle Serum Shot?

For best results, use the serum in your evening skincare routine. Begin with 2–3 applications per week and gradually increase frequency based on skin comfort. Always apply sunscreen during the day, as skin may feel more sensitive after microneedle-inspired treatments. Avoid using on irritated or compromised skin and follow with a soothing moisturizer.


How long does it take to see results from a PDRN & Exosome Microneedle Serum Shot?

With consistent use, visible improvements such as smoother skin texture, better hydration, and improved skin resilience may be noticed within 3–4 weeks. Results vary depending on individual skin type, routine consistency, and overall skincare regimen.

What is the role of Melazero? 

Melazero™, sourced from Arisaema amurense, is a next-generation patented brightening agent that helps enhance skin clarity through dual brightening mechanisms.


How does Melazero™ work?

Melazero™ supports skin brightening in two ways. First, it helps control how melanin is produced. Second, it activates autophagy, a natural cellular process.

Think of autophagy like a clean-up crew inside the skin cell—breaking down excess melanin into smaller components that the body can naturally reuse.

We act solely as a third-party manufacturer. We globally source active ingredients that are registered trademarks of their respective companies. Any data, studies, technical information, or references displayed on this website are derived from publicly available sources or materials provided by the respective trademark owners and are provided for general informational purposes only.

No affiliation, endorsement, sponsorship, or partnership with any trademark owner or brand is implied unless expressly stated. All trademarks, trade names, logos, and intellectual property rights remain the property of their respective owners.

As a third-party manufacturer, we do not assume liability for brand claims, marketing representations, or end-use outcomes of the finished products. Product claims, performance, and results may vary based on individual skin type, skin texture, ethnicity, usage conditions, and other personal factors. Results are not guaranteed.

The information provided on this website does not constitute medical advice, diagnosis, or treatment. Use of any product should be in accordance with applicable laws, regulations, labeling instructions, and professional guidance in India.

The claims made about this product are based on ingredient-level research and consumer use studies. These statements have not been evaluated by any regulatory authority. This product is not intended to replace medical treatment or dermatological advice.