Cica Micro-Shot Infusion Liquid Micro-Needling Serum (Patented Korean Spicule Technology)

PDRN 2%

PDRN (Polydeoxyribonucleotide) is a bioactive DNA fragment naturally derived from salmon. These low–molecular weight nucleotides are known for their ability to support skin cell regeneration and tissue repair, making them a powerful ingredient in advanced skin-rejuvenation formulations.

PDRN closely resembles human DNA in structure, which allows for high skin compatibility and optimal biological activity. It works by activating A2A adenosine receptors, helping to:

• Stimulate collagen synthesis
• Reduce inflammation
• Strengthen the skin barrier

Intelligent Regenerative Skincare

Exosomes 2%

Exosomes are extracellular vesicles involved in intercellular signaling. They carry bioactive molecules such as proteins, lipids, and nucleic acids that influence cellular repair and regeneration pathways.
For cosmetic use, exosomes are typically derived from mesenchymal stem cell sources and formulated into topical products to support skin rejuvenation and barrier function.

Exosome-based serums are advanced cosmetic formulations designed to support skin regeneration and anti-aging through enhanced cellular communication.

Melazero™ 1% (Japan)

Patented third-generation depigmenting active

Derived from Arisaema amurense, Melazero™ is a patented third-generation brightening active with a novel mechanism of action.

Hyperpigmentation is a widespread skin concern resulting from increased melanin synthesis. Melanin, derived from the amino acid tyrosine, is a group of pigments that determine skin color, primarily in the form of eumelanin and pheomelanin.

Most conventional brightening actives focus solely on reducing new melanin production, offering limited benefit against pigment already deposited in the skin.

This is where Melazero™ stands apart. In addition to controlling melanin synthesis, Melazero™ helps reduce existing pigment accumulation beneath the skin while limiting further melanocyte activity—delivering a more comprehensive and effective brightening approach. Let us explore the advanced mechanism behind Melazero™ and its superior skin-brightening action.

Niacinamide 5%

Niacinamide 5% is a high-performance skincare active that helps refine skin texture, minimize blemishes, and enhance overall skin quality.

Also known as vitamin B3, niacinamide is a water-soluble vitamin celebrated for its wide-ranging skin benefits. Commonly used in advanced serums and moisturizers, a 5% strength provides effective results without compromising skin comfort.

Alpha Arbutin 2%

Alpha Arbutin, a bioengineered derivative of bearberry extract, is a well-recognized brightening ingredient known for its ability to regulate melanin production. By helping fade dark spots and discoloration, it supports clearer, more radiant skin. A 2% formulation offers optimal performance, providing noticeable skin tone correction and brightening benefits.

Sodium Hyaluronate 8M – 1.5%

Sodium Hyaluronate 8M at 1.5% provides deep, long-lasting hydration by attracting and retaining moisture on the skin surface. Its high molecular weight structure enhances skin suppleness, smoothness, and plumpness while reinforcing the skin barrier and aiding recovery after micro-spicule action.

 
Ethyl Ascorbic Acid 3%

 Ethyl Ascorbic Acid 3% is a stable, water-soluble form of vitamin C that penetrates the skin effectively to provide antioxidant protection and visible brightening. Commonly used in modern skincare formulations, it offers improved stability compared to traditional vitamin C. Its balanced pH range makes it suitable for cosmetic use, supporting a brighter, healthier-looking complexion.

 
Micro-Spicules (0.2%)

“Spicule-based skincare is a microneedling-inspired, needle-free delivery technology designed to enhance topical absorption.”

Melazero™ demonstrates superior brightening efficacy compared to conventional depigmenting agents.
Clinical evaluations indicate that Melazero™ delivers up to 2× greater pigment reduction than alpha-arbutin. At a concentration of 1%, Melazero™ exhibits stronger melanin inhibition than 2% kojic acid, without inducing the cellular toxicity associated with higher kojic acid concentrations.

Unlike traditional brightening actives that require up to four weeks to show visible results, Melazero™ provides noticeable improvement in skin tone within two weeks, enabling faster and more effective pigmentation correction.

Spicule
Clinical studies on crow’s-feet reveal that when spicules are combined with active ingredients, skin density improves significantly compared to actives alone. Additional findings show that spicules increase skin permeability, enabling deeper and more efficient delivery of topical actives. By creating ultra-fine micro-channels in the epidermis, spicules help transcend the skin’s natural barrier—unlocking the full potential of peptides, retinoids, and antioxidants.

Within 7 Days

• Improved hydration
• Visible glow
• Smoother skin texture

Within 14 Days

• Reduction in dullness
• Early improvement in uneven tone
• Skin looks healthier and plumper

Within 21–28 Days

• Noticeable reduction in pigmentation
• Enhanced brightness and clarity
• Improved elasticity and skin firmness

After 4–6 Weeks

• Even skin tone
• Long-term pigmentation control
• Strengthened skin barrier and radiance

(Results may vary based on skin type and adherence to usage protocol)

Skin Sensitivity Check

At Healthy Nutrea, skincare is approached with care and responsibility. Our goal is not just results, but safety and confidence with every use. To help ensure suitability, we recommend performing a skin compatibility test before first use.

How to Perform the Test

1. Clean a small area on the upper forearm and apply a small amount of the product
2. Allow it to remain undisturbed for 15–20 minutes (up to a maximum of 30 minutes)
3. If itching, redness, burning, blistering, or irritation occurs, rinse the area thoroughly and discontinue use

Important Note

This test is intended only to identify early signs of local skin irritation. It does not guarantee similar results when applied to other areas of the body, including the face, or after prolonged or repeated use.
This test does not evaluate underlying skin conditions and should not be used to diagnose hypersensitivity or allergic contact dermatitis.

 Product Information & Safety Notes

Natural variations may occur. Patch testing is recommended. Discontinue use if irritation develops. External use only. Store appropriately. Results may vary.

WHEN TO USE

✘ Do not use daily

✘ Avoid combining with other exfoliating or retinol products on the same night

FREQUENCY SCHEDULE

• Apply 3-4 times a week
• After Skin adapts, preferred use is alternate days

For best results, use at night, you can use your moisturizer after applying Micro Cica Shot serum.

Avoid if you have a sensitive skin, Acne and redness

Cautious

Exposure to heat, LED light therapy, or stimulation from skincare tools (such as LED masks, RF, or ultrasonic devices) may increase skin sensitivity and could lead to irritation. Concurrent use is not advised.